Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.
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Overview of the Extrusion-Spheronization Process
Capsugel is well versed in using drug layering and modified-release coat layering to achieve a range of dissolution profiles in multiparticulate format. Capsugel has extensive experience in designing, formulating and scaling mulitparticulate dosage forms at feasibility, pilot and commercial scales.
The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts. By continuing to use this website, you agree that we may store and access cookies on your device.
The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads that result.
For technical reasons, the resulting pellets are larger than micrometers. The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates. Register for An Account Already a member? The process consists of five operations. Primary packaging in either vials or sachets and secondary packaging services are also available. You can disable cookies but parts of our website may not work.
Please read our updated Cookies Policy for information about which cookies we use and the information we collect. Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions for subsequent coating.
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The Extrusion Spheronization Processs
By Product Development Site. The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert.
Extrusion / Spheronization – Glatt Integrated Process Solutions
It is useful for making dense granules for controlled-release solid oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, modified, or sustained-release. The process consists of four process steps: The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. The final drying ensures the pellet hardness.
The wet mass is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization.
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Common applications include delayed release, extended release, pulsatile release, and fixed dose combinations. Just the way you need it. Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed with representative case studies.
In other industries, the size of the pellets can be several spherohization. The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms uniform spheres from the extrudate “rope”.