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Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.

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Overview of the Extrusion-Spheronization Process

Capsugel is well versed in using drug layering and modified-release coat layering to achieve a range of dissolution profiles in multiparticulate format. Capsugel has extensive experience in designing, formulating and scaling mulitparticulate dosage forms at feasibility, pilot and commercial scales.

The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts. By continuing to use this website, you agree that we may store and access cookies on your device.

The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads that result.

For technical reasons, the resulting pellets are larger than micrometers. The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates. Register for An Account Already a member? The process consists of five operations. Primary packaging in either vials or sachets and secondary packaging services are also available. You can disable cookies but parts of our website may not work.

Please read our updated Cookies Policy for information about which cookies we use and the information we collect. Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions for subsequent coating.


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The Extrusion Spheronization Processs

Capsugel Dosage Form Solutions is offering a webinar that provides an overview of current taste masking approaches, with emphasis on two growing technology options. In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for most applications. By visiting our website or using services provided by Lonza, you anf accepting the practices described in the Privacy Policy.

By Product Development Site. The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert.

Extrusion / Spheronization – Glatt Integrated Process Solutions

It is useful for making dense granules for controlled-release solid oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, modified, or sustained-release. The process consists of four process steps: The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. The final drying ensures the pellet hardness.

The wet mass is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization.

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Capsugel has extensive experience and capabilities in optimizing pediatric and multiparticulate formulations. For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added. Please note that Lonza has updated its Privacy Policy.


Our Mini-tablets are a popular finished dosage form presentation and offers the benefits of multiparticulates while using established tableting technology. The dry, mixed, powdery active substances are kneaded into a dough with a liquid. By clicking “I Agree”, you confirm that you are above the age of 16, that you have read and understood the Privacy Policy and the Cookies Policy, and that you agree to the collection, use and processing of your Personal Information by Lonza in accordance with said policies.

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We also use cookies on our websites. Agglomeration through extrusion and spheronization is one of the oldest techniques for manufacturing pellets. The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for dosing. Capsugel offers a drug delivery technology to provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings. This dough then pressed through an extruder.

Common applications include delayed release, extended release, pulsatile release, and fixed dose combinations. Just the way you need it. Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed with representative case studies.

In other industries, the size of the pellets can be several spherohization. The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms uniform spheres from the extrudate “rope”.